8CW2
Crystal structure of TDP1 complexed with compound XZ760
Summary for 8CW2
Entry DOI | 10.2210/pdb8cw2/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 4-({(4R)-7-phenyl-2-[4-(2-{[4-(pyridin-2-yl)phenyl]methoxy}ethyl)phenyl]imidazo[1,2-a]pyridin-3-yl}amino)benzene-1,2-dicarboxylic acid, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, dna binding protein, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 106171.84 |
Authors | Lountos, G.T.,Zhao, X.Z.,Wang, W.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke, T.R. (deposition date: 2022-05-18, release date: 2023-04-12, Last modification date: 2023-10-25) |
Primary citation | Zhao, X.Z.,Wang, W.,Lountos, G.T.,Kiselev, E.,Tropea, J.E.,Needle, D.,Pommier, Y.,Burke Jr., T.R. Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4:334-343, 2023 Cited by PubMed: 37181631DOI: 10.1039/d2cb00230b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.811 Å) |
Structure validation
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