8CVO
Cutibacterium acnes 30S ribosomal subunit with Sarecycline bound, head domain only in the local refined map
Summary for 8CVO
| Entry DOI | 10.2210/pdb8cvo/pdb |
| Related | 8CRX 8CVM |
| EMDB information | 27011 |
| Descriptor | 16S ribosomal RNA, Sarecycline, MAGNESIUM ION, ... (12 entities in total) |
| Functional Keywords | ribosome, sarecycline, acne, antibiotic |
| Biological source | Cutibacterium acnes More |
| Total number of polymer chains | 9 |
| Total formula weight | 631407.10 |
| Authors | Lomakin, I.B.,Devarkar, S.C.,Bunick, C.G. (deposition date: 2022-05-18, release date: 2023-03-15, Last modification date: 2023-04-19) |
| Primary citation | Lomakin, I.B.,Devarkar, S.C.,Patel, S.,Grada, A.,Bunick, C.G. Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism. Nucleic Acids Res., 51:2915-2930, 2023 Cited by PubMed: 36864821DOI: 10.1093/nar/gkad103 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.95 Å) |
Structure validation
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