8CUH

Crystal structure of human TEAD2 complexed with its inhibitor TM2.

Summary for 8CUH

• Entry DOI: 10.2210/pdb8cuh/pdb
• Descriptor: Transcriptional enhancer factor TEF-4, 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide (3 entities in total)
• Functional Keywords: transcription factor, transcription-transcription inhibitor complex, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 55849.31

Authors

Liu, S.,Luo, X. (deposition date: 2022-05-17, release date: 2022-11-23, Last modification date: 2023-10-25)

• Primary citation: Hu, L.,Sun, Y.,Liu, S.,Erb, H.,Singh, A.,Mao, J.,Luo, X.,Wu, X.; Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode.; Elife, 11:-, 2022; PubMed: 36398861; DOI: 10.7554/eLife.80210

Experimental method

X-RAY DIFFRACTION (2.4 Å)