8CUH

Crystal structure of human TEAD2 complexed with its inhibitor TM2.

8CUH の概要

• エントリーDOI: 10.2210/pdb8cuh/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide (3 entities in total)
• 機能のキーワード: transcription factor, transcription-transcription inhibitor complex, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55849.31

構造登録者

Liu, S.,Luo, X. (登録日: 2022-05-17, 公開日: 2022-11-23, 最終更新日: 2023-10-25)

• 主引用文献: Hu, L.,Sun, Y.,Liu, S.,Erb, H.,Singh, A.,Mao, J.,Luo, X.,Wu, X.; Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode.; Elife, 11:-, 2022; PubMed: 36398861; DOI: 10.7554/eLife.80210

実験手法

X-RAY DIFFRACTION (2.4 Å)