8CTF

The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid

Summary for 8CTF

Entry DOI	10.2210/pdb8ctf/pdb
Related	7V04
Descriptor	Polymerase acidic protein, ACETATE ION, 3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	drug discovery, metal-binding pharmacophore, isosteres, influenza endonuclease, viral protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Influenza A virus
Total number of polymer chains	1
Total formula weight	22808.69
Authors	Kohlbrand, A.J.,Stokes, R.W.,Karges, J.,Seo, H.,Sankaran, B.,Cohen, S.M. (deposition date: 2022-05-14, release date: 2022-12-21, Last modification date: 2023-10-25)
Primary citation	Stokes, R.W.,Kohlbrand, A.J.,Seo, H.,Sankaran, B.,Karges, J.,Cohen, S.M. Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors. Acs Med.Chem.Lett., 14:75-82, 2023 Cited by PubMed: 36655124 DOI: 10.1021/acsmedchemlett.2c00434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation