8CT7

Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436

8CT7 の概要

• エントリーDOI: 10.2210/pdb8ct7/pdb
• 分子名称: Integrase, (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: viral dna integration, dna binding, ledgf binding, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18494.79

構造登録者

Gupta, K.,Van Duyne, G.D.,Eilers, G.,Bushman, F.D. (登録日: 2022-05-13, 公開日: 2023-02-15, 最終更新日: 2023-10-25)

• 主引用文献: Eilers, G.,Gupta, K.,Allen, A.,Montermoso, S.,Murali, H.,Sharp, R.,Hwang, Y.,Bushman, F.D.,Van Duyne, G.; Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization.; Plos Pathog., 19:e1011097-e1011097, 2023; PubMed: 36867659; DOI: 10.1371/journal.ppat.1011097

実験手法

X-RAY DIFFRACTION (2.13 Å)