8CSG

Human PRMT5:MEP50 structure with Fragment 1 and MTA Bound

8CSG の概要

• エントリーDOI: 10.2210/pdb8csg/pdb
• 分子名称: Protein arginine N-methyltransferase 5, Methylosome protein 50, 6-bromo-1H-pyrrolo[3,2-b]pyridin-5-amine, ... (7 entities in total)
• 機能のキーワード: mtap, methyl transferase, fragment-based lead discovery, fbdd, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112577.91

構造登録者

Gunn, R.J.,Lawson, J.D.,Smith, C.R. (登録日: 2022-05-12, 公開日: 2022-10-05, 最終更新日: 2024-05-22)

• 主引用文献: Smith, C.R.,Kulyk, S.,Ahmad, M.U.D.,Arkhipova, V.,Christensen, J.G.,Gunn, R.J.,Ivetac, A.,Ketcham, J.M.,Kuehler, J.,Lawson, J.D.,Thomas, N.C.,Wang, X.,Marx, M.A.; Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits.; Rsc Med Chem, 13:1549-1564, 2022; PubMed: 36545438; DOI: 10.1039/d2md00163b

実験手法

X-RAY DIFFRACTION (2.48 Å)