8CRC

Structure of human Plk1 PBD in complex with Allopole-A

8CRC の概要

• エントリーDOI: 10.2210/pdb8crc/pdb
• 分子名称: Serine/threonine-protein kinase PLK1, GLYCEROL, 7-chloro-4-(cyclopropylmethyl)-1-thioxo-2,4-dihydrothieno[2,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one, ... (4 entities in total)
• 機能のキーワード: kinase, serine/threonine protein kinase, small molecule, allosteric inhibitor, cell cycle, localization, cell division, mitosis, nucleus, phosphoprotein, transferase, phosphopeptide binding domain, transferase-inhibitor complex
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26773.02

構造登録者

Kirsch, K.,Park, J.E.,Lee, K.S. (登録日: 2023-03-08, 公開日: 2023-08-16, 最終更新日: 2023-08-30)

• 主引用文献: Park, J.E.,Kirsch, K.,Lee, H.,Oliva, P.,Ahn, J.I.,Ravishankar, H.,Zeng, Y.,Fox, S.D.,Kirby, S.A.,Badhwar, P.,Andresson, T.,Jacobson, K.A.,Lee, K.S.; Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.; Proc.Natl.Acad.Sci.USA, 120:e2305037120-e2305037120, 2023; PubMed: 37603740; DOI: 10.1073/pnas.2305037120

実験手法

X-RAY DIFFRACTION (1.65 Å)