8CQ9

Mycobacterium tuberculosis dihydrofolate reductase in complex with 5-(cyclopropylethynyl)-6-(4-(trifluoromethyl)phenyl)pyrimidine-2,4-diamine

Summary for 8CQ9

• Entry DOI: 10.2210/pdb8cq9/pdb
• Descriptor: Dihydrofolate reductase, 5-[(~{E})-2-cyclopropylethenyl]-6-[4-(trifluoromethyl)phenyl]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (7 entities in total)
• Functional Keywords: dihydrofolate reductase mycobacterium tuberculosis, biosynthetic protein
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 38615.41

Authors

Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G. (deposition date: 2023-03-04, release date: 2024-03-13)

• Primary citation: Kirkman, T.J.,Dias, M.V.B.,Coyne, A.G.; Expansion of a series of pyrimidine derivatives utilising fragment-based merging leads to increased affinity to Mycobacterium tuberculosis dihydrofolate reductase (unpublished currently); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)