8CPR

G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation crystallized in sodium potassium phosphate buffer

8CPR の概要

• エントリーDOI: 10.2210/pdb8cpr/pdb
• 分子名称: GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: kras, colorectal cancer, ras signalling, cancer stem cells, ras-driven metastasis, kras structure, kras mutations, oncoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19929.10

構造登録者

Moche, M.,Jungholm, O.,Strandback, E.,Ampah-Korsah, H.,Nyman, T.,Orwar, O. (登録日: 2023-03-03, 公開日: 2024-06-12, 最終更新日: 2024-09-11)

• 主引用文献: Jungholm, O.,Trkulja, C.,Moche, M.,Srinivasa, S.P.,Christakopoulou, M.N.,Davidson, M.,Reymer, A.,Jardemark, K.,Fogaca, R.L.,Ashok, A.,Jeffries, G.,Ampah-Korsah, H.,Strandback, E.,Andrell, J.,Nyman, T.,Nouairia, G.,Orwar, O.; Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody.; Sci Rep, 14:19656-19656, 2024; PubMed: 39179604; DOI: 10.1038/s41598-024-70217-9

実験手法

X-RAY DIFFRACTION (2 Å)