8CPD

Cryo-EM structure of CRaf dimer with 14:3:3

Summary for 8CPD

• Entry DOI: 10.2210/pdb8cpd/pdb
• Related: 8chf
• EMDB information: 16779
• Descriptor: RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein zeta isoform X1 (2 entities in total)
• Functional Keywords: kinase, complex, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 202585.98

Authors

Dedden, D.,Graedler, U.,Schwarz, D.,Thomsen, M.,Leuthner, B.,Schneider, E.,Nitsche, J. (deposition date: 2023-03-02, release date: 2024-02-21, Last modification date: 2024-02-28)

• Primary citation: Dedden, D.,Nitsche, J.,Schneider, E.V.,Thomsen, M.,Schwarz, D.,Leuthner, B.,Gradler, U.; Cryo-EM Structures of CRAF 2 /14-3-3 2 and CRAF 2 /14-3-3 2 /MEK1 2 Complexes.; J.Mol.Biol., 436:168483-168483, 2024; PubMed: 38331211; DOI: 10.1016/j.jmb.2024.168483

Experimental method

ELECTRON MICROSCOPY (3.46 Å)