8CPD
Cryo-EM structure of CRaf dimer with 14:3:3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | RAF proto-oncogene serine/threonine-protein kinase | polymer | 648 | 73184.5 | 2 | UniProt (P04049) Pfam (PF02196) Pfam (PF00130) Pfam (PF00069) In PDB | Homo sapiens (human) | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 2 | C, D | 14-3-3 protein zeta isoform X1 | polymer | 247 | 28108.5 | 2 | UniProt (A0A9R0D7T1) Pfam (PF00244) In PDB | Spodoptera frugiperda (fall armyworm) |
Sequence modifications
A, B: 1 - 648 (UniProt: P04049)
| PDB | External Database | Details |
|---|---|---|
| Asp 341 | Tyr 341 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 202586.0 | |
| All* | Total formula weight | 202586.0 |
