8COE

complement C5 in complex with the LCP0195 nanobody

8COE の概要

• エントリーDOI: 10.2210/pdb8coe/pdb
• 分子名称: Complement C5 beta chain, Complement C5 alpha chain, LCP0195, ... (4 entities in total)
• 機能のキーワード: innate immunity, complement, terminal pathway, nanobody, antigen-antibody complex, immune system
• 由来する生物種: Lama glama; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 200854.66

構造登録者

Andersen, G.R.,Pedersen, D.V. (登録日: 2023-02-28, 公開日: 2024-01-03)

• 主引用文献: Jindal, S.,Pedersen, D.V.,Gera, N.,Chandler, J.,Patel, R.,Neill, A.,Cone, J.,Zhang, Y.,Yuan, C.X.,Millman, E.E.,Carlin, D.,Puffer, B.,Sheridan, D.,Andersen, G.R.,Tamburini, P.; Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration.; Mol.Immunol., 165:29-41, 2023; PubMed: 38142486; DOI: 10.1016/j.molimm.2023.12.004

実験手法

X-RAY DIFFRACTION (4.2 Å)