8CMX

Structure of sphingosine-1-phosphate lyase (SPL) from Aspergillus fumigatus

Summary for 8CMX

• Entry DOI: 10.2210/pdb8cmx/pdb
• Related: 8AYF
• Descriptor: Sphinganine-1-phosphate aldolase BST1, putative (1 entity in total)
• Functional Keywords: sphingosine, sphingosine-1-phosphate, s1p, lyase
• Biological source: Aspergillus fumigatus
• Total number of polymer chains: 2
• Total formula weight: 109202.14

Authors

Catalano, F.,Pampalone, G. (deposition date: 2023-02-21, release date: 2024-01-03)

• Primary citation: Cellini, B.,Pampalone, G.,Camaioni, E.,Pariano, M.,Catalano, F.,Zelante, T.,Dindo, M.,Macchioni, L.,Di Veroli, A.,Galarini, R.,Paoletti, F.,Davidescu, M.,Stincardini, C.,Vascelli, G.,Bellet, M.M.,Saba, J.,Giovagnoli, S.,Giardina, G.,Romani, L.,Costantini, C.; Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study.; Sci Rep, 13:22692-22692, 2023; PubMed: 38123809; DOI: 10.1038/s41598-023-50121-4

Experimental method

X-RAY DIFFRACTION (3.46 Å)