8CME

Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Membrane peptide M176-190

Summary for 8CME

• Entry DOI: 10.2210/pdb8cme/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, Human leukocyte antigen DR beta chain allotype DR1 (DRB1*0101), Membrane protein, ... (6 entities in total)
• Functional Keywords: hla-ii, hla-dr, hla-dr1, human leukocyte antigen, major histocompatibility complex, major histocompatibility complex class 2, sars-cov-2, coronavirus, covid-19, membrane, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 136531.68

Authors

MacLachlan, B.J.,Mason, G.H.,Sourfield, D.O.,Godkin, A.J.,Rizkallah, P.J. (deposition date: 2023-02-19, release date: 2023-07-26, Last modification date: 2023-08-02)

• Primary citation: Chen, Y.,Mason, G.H.,Scourfield, D.O.,Greenshields-Watson, A.,Haigh, T.A.,Sewell, A.K.,Long, H.M.,Gallimore, A.M.,Rizkallah, P.,MacLachlan, B.J.,Godkin, A.; Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.; Cell Rep, 42:112827-112827, 2023; PubMed: 37471227; DOI: 10.1016/j.celrep.2023.112827

Experimental method

X-RAY DIFFRACTION (2.26 Å)