8CMD

Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Spike peptide S761-775

8CMD の概要

• エントリーDOI: 10.2210/pdb8cmd/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, Human leukocyte antigen DR beta chain allotype DR1 (DRB1*0101), Spike protein S2', ... (5 entities in total)
• 機能のキーワード: hla-ii, hla-dr, hla-dr1, human leukocyte antigen, major histocompatibility complex, major histocompatibility complex class 2, sars-cov-2, coronavirus, covid-19, spike, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 136832.91

構造登録者

MacLachlan, B.J.,Mason, G.H.,Sourfield, D.O.,Godkin, A.J.,Rizkallah, P.J. (登録日: 2023-02-19, 公開日: 2023-07-26, 最終更新日: 2023-08-02)

• 主引用文献: Chen, Y.,Mason, G.H.,Scourfield, D.O.,Greenshields-Watson, A.,Haigh, T.A.,Sewell, A.K.,Long, H.M.,Gallimore, A.M.,Rizkallah, P.,MacLachlan, B.J.,Godkin, A.; Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.; Cell Rep, 42:112827-112827, 2023; PubMed: 37471227; DOI: 10.1016/j.celrep.2023.112827

実験手法

X-RAY DIFFRACTION (2.54 Å)