8CHE

TLT-1 binding Fab of the bispecific antibody HMB-001 in complex with the TLT-1 stalk peptide

Summary for 8CHE

• Entry DOI: 10.2210/pdb8che/pdb
• Descriptor: Fab heavy chain, Fab light chain, Trem-like transcript 1 protein, ... (4 entities in total)
• Functional Keywords: tlt-1, fab, bispecific antibody, hmb-001, blood clotting
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 102035.60

Authors

Johansson, E.,Schluckebier, G. (deposition date: 2023-02-07, release date: 2023-12-27, Last modification date: 2024-07-10)

• Primary citation: Gandhi, P.S.,Zivkovic, M.,Ostergaard, H.,Bonde, A.C.,Elm, T.,Lovgreen, M.N.,Schluckebier, G.,Johansson, E.,Olsen, O.H.,Olsen, E.H.N.,de Bus, I.A.,Bloem, K.,Alskar, O.,Rea, C.J.,Bjorn, S.E.,Schutgens, R.E.,Sorensen, B.,Urbanus, R.T.,Faber, J.H.; A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders; Nat Cardiovasc Res, 3:166-185, 2024; DOI: 10.1038/s44161-023-00418-4

Experimental method

X-RAY DIFFRACTION (1.49 Å)