8CH6
Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).
This is a non-PDB format compatible entry.
Summary for 8CH6
Entry DOI | 10.2210/pdb8ch6/pdb |
EMDB information | 16658 |
Descriptor | Small nuclear ribonucleoprotein E, Splicing factor 3B subunit 1, PHD finger-like domain-containing protein 5A, ... (53 entities in total) |
Functional Keywords | activated spliceosome, aquarius, prp2, splicing |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 59 |
Total formula weight | 3668283.05 |
Authors | Cretu, C.,Schmitzova, J.,Pena, V. (deposition date: 2023-02-07, release date: 2023-05-10, Last modification date: 2023-06-14) |
Primary citation | Schmitzova, J.,Cretu, C.,Dienemann, C.,Urlaub, H.,Pena, V. Structural basis of catalytic activation in human splicing. Nature, 617:842-850, 2023 Cited by PubMed: 37165190DOI: 10.1038/s41586-023-06049-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (5.9 Å) |
Structure validation
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