8CE3

Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with 3D fragment 2548

8CE3 の概要

• エントリーDOI: 10.2210/pdb8ce3/pdb
• 分子名称: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, 1,2-ETHANEDIOL, (3~{S})-1-ethanoyl-3-(4-methylphenyl)piperidine-3-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: glycosyltransferase, fragment, carbohydrate
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119938.42

構造登録者

Gilio, A.K.,Darby, J.F.,Wu, L.,Davies, G.J. (登録日: 2023-02-01, 公開日: 2024-02-21, 最終更新日: 2025-09-03)

• 主引用文献: Downes, T.D.,Jones, S.P.,Firth, J.D.,Darby, J.F.,Gilio, A.K.,Klein, H.F.,Blakemore, D.C.,de Fusco, C.,Roughley, S.D.,Vidler, L.R.,Whatton, M.A.,Woolford, A.J.A.,Wrigley, G.L.,Hubbard, R.E.,Wu, L.,Davies, G.J.,O'Brien, P.; Design, Modular Synthesis and Screening of 58 Shape-Diverse 3-D Fragments; Chemrxiv, 2025; DOI: 10.26434/chemrxiv-2025-mxs07

実験手法

X-RAY DIFFRACTION (1.89 Å)