8CDW
CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 7-(1-methyl-1H-pyrazol-4-yl)-N-[4-(1-methylpiperidin-4-yl)phenyl]quinazolin-2-amine
Summary for 8CDW
Entry DOI | 10.2210/pdb8cdw/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase kinase 1, ~{N}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine (3 entities in total) |
Functional Keywords | protein kinase, signaling protein, transferase, map4k1, hematopoietic progenitor kinase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 69518.51 |
Authors | |
Primary citation | Toure, M.,Johnson, T.,Li, B.,Schmidt, R.,Ma, H.,Neagu, C.,Lopez, A.U.,Wang, Y.,Guler, S.,Xiao, Y.,Henkes, R.,Ho, K.,Zhang, S.,Chu, C.L.,Gundra, U.M.,Porichis, F.,Li, L.,Maurer, C.K.,Fang, Z.,Musil, D.,DiPoto, M.,Friis, E.,Jones, R.,Jones, C.,Cummings, J.,Chekler, E.,Tanzer, E.M.,Huck, B.,Sherer, B. Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorg.Med.Chem., 92:117423-117423, 2023 Cited by PubMed: 37531921DOI: 10.1016/j.bmc.2023.117423 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.941 Å) |
Structure validation
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