8CDW
CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 7-(1-methyl-1H-pyrazol-4-yl)-N-[4-(1-methylpiperidin-4-yl)phenyl]quinazolin-2-amine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 307 | 34360.8 | 2 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | C, D (A, B) | ~{N}-[4-(1-methylpiperidin-4-yl)phenyl]-7-(1-methylpyrazol-4-yl)quinazolin-2-amine | non-polymer | 398.5 | 2 | Chemie (UES) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 191 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 307 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Glu 165 | Thr 165 | conflict |
| Glu 171 | Ser 171 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68721.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 797.0 | |
| All* | Total formula weight | 69518.5 |
