8CDG

Crystal structure of human IL-17A cytokine in complex with macrocycle

8CDG の概要

• エントリーDOI: 10.2210/pdb8cdg/pdb
• 分子名称: Interleukin-17A, (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid (2 entities in total)
• 機能のキーワード: inhibitor, complex, cytokine, macrocycle
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29405.15

構造登録者

Schulze, M.-S. (登録日: 2023-01-30, 公開日: 2023-12-06)

• 主引用文献: Shaw, D.J.,Waters, L.C.,Strong, S.L.,Schulze, M.E.D.,Greetham, G.M.,Towrie, M.,Parker, A.W.,Prosser, C.E.,Henry, A.J.,Lawson, A.D.G.,Carr, M.D.,Taylor, R.J.,Hunt, N.T.,Muskett, F.W.; Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.; Chem Sci, 14:7524-7536, 2023; PubMed: 37449080; DOI: 10.1039/d3sc00728f

実験手法

X-RAY DIFFRACTION (2.9 Å)