8CCZ

Crystal structure of human Sirt3 in complex with an inhibiting HIV1 Tat-37-59 peptide

Summary for 8CCZ

Entry DOI	10.2210/pdb8ccz/pdb
Descriptor	NAD-dependent protein deacetylase sirtuin-3, mitochondrial, Protein Tat, ZINC ION, ... (4 entities in total)
Functional Keywords	sirtuin, inhibitor, hiv, complex, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	68293.53
Authors	Adolph, R.S.,Steegborn, C. (deposition date: 2023-01-28, release date: 2023-05-10, Last modification date: 2024-02-07)
Primary citation	Adolph, R.S.,Beck, E.,Schweimer, K.,Di Fonzo, A.,Weyand, M.,Rosch, P.,Wohrl, B.M.,Steegborn, C. Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein. Life, 13:-, 2023 Cited by PubMed: 37109478 DOI: 10.3390/life13040949 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation