8CBF

SARS-CoV-2 Delta-RBD complexed with Omi-42 and Beta-49 Fabs

8CBF の概要

• エントリーDOI: 10.2210/pdb8cbf/pdb
• 関連するPDBエントリー: 8CBD 8CBE
• 分子名称: Spike protein S1, Beta-49 light chain, Beta-49 heavy chain, ... (10 entities in total)
• 機能のキーワード: sars-cov-2, ba.4 mab, ba.5 mab, rbd, ba.4/5-1, ba.4/5-2, ba.4/5-5, beta-49, omi-42, viral protein/immune system, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 118571.43

構造登録者

Zhou, D.,Ren, J.,Stuart, D.I. (登録日: 2023-01-25, 公開日: 2024-02-07, 最終更新日: 2024-11-20)

主引用文献

Liu, C.,Das, R.,Dijokaite-Guraliuc, A.,Zhou, D.,Mentzer, A.J.,Supasa, P.,Selvaraj, M.,Duyvesteyn, H.M.E.,Ritter, T.G.,Temperton, N.,Klenerman, P.,Dunachie, S.J.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.
Emerging variants develop total escape from potent monoclonal antibodies induced by BA.4/5 infection.
Nat Commun, 15:3284-3284, 2024

PubMed Abstract: The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally. Since the emergence of BA.4/5, SARS-CoV-2 has continued to accrue mutations in the S protein, to understand this we characterize neutralization of a large panel of variants and demonstrate a steady attrition of neutralization by the panel of BA.4/5 mAbs culminating in total loss of function with recent XBB.1.5.70 variants containing the so-called 'FLip' mutations at positions 455 and 456. Interestingly, activity of some mAbs is regained on the recently reported variant BA.2.86.

PubMed: 38627386
DOI: 10.1038/s41467-024-47393-3

実験手法

X-RAY DIFFRACTION (2.33 Å)