8CB1

Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in complex with N-PNT-DNM 15

8CB1 の概要

• エントリーDOI: 10.2210/pdb8cb1/pdb
• 分子名称: Lysosomal alpha-glucosidase (76 kDa), 1,2-ETHANEDIOL, (2R,3R,4R,5S)-2-(hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol, ... (13 entities in total)
• 機能のキーワード: gaa, pompe disease, pharmacological chaperone, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102042.72

構造登録者

Sulzenbacher, G.,Roig-Zamboni, V.,Overkleeft, H.,Artola, M. (登録日: 2023-01-25, 公開日: 2023-09-13, 最終更新日: 2023-11-15)

• 主引用文献: van der Gracht, D.,Rowland, R.J.,Roig-Zamboni, V.,Ferraz, M.J.,Louwerse, M.,Geurink, P.P.,Aerts, J.M.F.G.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Artola, M.; Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases.; Chem Sci, 14:9136-9144, 2023; PubMed: 37655021; DOI: 10.1039/d3sc01021j

実験手法

X-RAY DIFFRACTION (1.75 Å)