8CB0
Crystal structure of dehydrogenase domain of Cylindrospermum stagnale NADPH-Oxidase 5 (NOX5) in complex with M41 and NADP+
Summary for 8CB0
Entry DOI | 10.2210/pdb8cb0/pdb |
Descriptor | Putative ferric reductase, FLAVIN-ADENINE DINUCLEOTIDE, 15-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-14-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2(7),3,5,9,11,13(17),14-octaen-8-one, ... (6 entities in total) |
Functional Keywords | ros, inhibitor, redox biology, oxidoreductase |
Biological source | Cylindrospermum stagnale |
Total number of polymer chains | 1 |
Total formula weight | 34256.42 |
Authors | Reis, J.,Mattevi, A. (deposition date: 2023-01-24, release date: 2023-09-27, Last modification date: 2024-04-10) |
Primary citation | Reis, J.,Gorgulla, C.,Massari, M.,Marchese, S.,Valente, S.,Noce, B.,Basile, L.,Torner, R.,Cox 3rd, H.,Viennet, T.,Yang, M.H.,Ronan, M.M.,Rees, M.G.,Roth, J.A.,Capasso, L.,Nebbioso, A.,Altucci, L.,Mai, A.,Arthanari, H.,Mattevi, A. Targeting ROS production through inhibition of NADPH oxidases. Nat.Chem.Biol., 19:1540-1550, 2023 Cited by PubMed: 37884805DOI: 10.1038/s41589-023-01457-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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