8CAP

Crystal structure of dehydrogenase domain of Cylindrospermum stagnale NADPH-Oxidase 5 (NOX5) in complex with CB28

Summary for 8CAP

Entry DOI	10.2210/pdb8cap/pdb
Descriptor	Putative ferric reductase, FLAVIN-ADENINE DINUCLEOTIDE, [4-[[(4~{E})-4-(furan-2-ylmethylidene)-2,3-dihydro-1~{H}-acridin-9-yl]carbonyl]piperazin-1-yl]-pyridin-2-yl-methanone (3 entities in total)
Functional Keywords	ros, inhibitor, redox biology, oxidoreductase
Biological source	Cylindrospermum stagnale
Total number of polymer chains	4
Total formula weight	133980.03
Authors	Reis, J.,Mattevi, A. (deposition date: 2023-01-24, release date: 2023-09-27, Last modification date: 2024-04-10)
Primary citation	Reis, J.,Gorgulla, C.,Massari, M.,Marchese, S.,Valente, S.,Noce, B.,Basile, L.,Torner, R.,Cox 3rd, H.,Viennet, T.,Yang, M.H.,Ronan, M.M.,Rees, M.G.,Roth, J.A.,Capasso, L.,Nebbioso, A.,Altucci, L.,Mai, A.,Arthanari, H.,Mattevi, A. Targeting ROS production through inhibition of NADPH oxidases. Nat.Chem.Biol., 19:1540-1550, 2023 Cited by PubMed: 37884805 DOI: 10.1038/s41589-023-01457-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation