8C9N

MiniCoV-ADDomer, a SARS-CoV-2 epitope presenting viral like particle

This is a non-PDB format compatible entry.

Summary for 8C9N

• Entry DOI: 10.2210/pdb8c9n/pdb
• EMDB information: 11730 16512
• Descriptor: Penton protein (1 entity in total)
• Functional Keywords: addomer, vlp, viral, like, particle, ad3, penton, base, vaccine, covid-19, covid, mini-covid, dodecahedron, pb, protein, adenovirus, human, virus like particle
• Biological source: Human adenovirus B3
• Total number of polymer chains: 60
• Total formula weight: 3997112.82

Authors

Bufton, J.C.,Capin, J.,Boruku, U.,Garzoni, F.,Schaffitzel, C.,Berger, I. (deposition date: 2023-01-23, release date: 2023-12-06, Last modification date: 2023-12-20)

Primary citation

Buzas, D.,Bunzel, A.H.,Staufer, O.,Milodowski, E.J.,Edmunds, G.L.,Bufton, J.C.,Vidana Mateo, B.V.,Yadav, S.K.N.,Gupta, K.,Fletcher, C.,Williamson, M.K.,Harrison, A.,Borucu, U.,Capin, J.,Francis, O.,Balchin, G.,Hall, S.,Vega, M.V.,Durbesson, F.,Lingappa, S.,Vincentelli, R.,Roe, J.,Wooldridge, L.,Burt, R.,Anderson, R.J.L.,Mulholland, A.J.,Hare, J.,Bailey, M.,Davidson, A.D.,Finn, A.,Morgan, D.,Mann, J.,Spatz, J.,Garzoni, F.,Schaffitzel, C.,Berger, I.
In vitro generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2.
Antib Ther, 6:277-297, 2023

PubMed Abstract: Due to COVID-19, pandemic preparedness emerges as a key imperative, necessitating new approaches to accelerate development of reagents against infectious pathogens.

PubMed: 38075238
DOI: 10.1093/abt/tbad024

Experimental method

ELECTRON MICROSCOPY (2.36 Å)