8C9J

Crystal structure of human NQO1 by serial femtosecond crystallography

Summary for 8C9J

• Entry DOI: 10.2210/pdb8c9j/pdb
• Descriptor: NAD(P)H dehydrogenase [quinone] 1, FLAVIN-ADENINE DINUCLEOTIDE, ACETATE ION, ... (4 entities in total)
• Functional Keywords: nqo1, flavoprotein, cancer, serial femtosecond crystallography, microcrystals, xfel, droplet injection, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 127008.82

Authors

Martin-Garcia, J.M.,Grieco, A.,Ruiz-Fresneda, M.A.,Pacheco-Garcia, J.L.,Pey, A.,Botha, S.,Ros, A. (deposition date: 2023-01-23, release date: 2023-06-28, Last modification date: 2024-02-07)

• Primary citation: Doppler, D.,Sonker, M.,Egatz-Gomez, A.,Grieco, A.,Zaare, S.,Jernigan, R.,Meza-Aguilar, J.D.,Rabbani, M.T.,Manna, A.,Alvarez, R.C.,Karpos, K.,Cruz Villarreal, J.,Nelson, G.,Yang, J.H.,Carrion, J.,Morin, K.,Ketawala, G.K.,Pey, A.L.,Ruiz-Fresneda, M.A.,Pacheco-Garcia, J.L.,Hermoso, J.A.,Nazari, R.,Sierra, R.,Hunter, M.S.,Batyuk, A.,Kupitz, C.J.,Sublett, R.E.,Lisova, S.,Mariani, V.,Boutet, S.,Fromme, R.,Grant, T.D.,Botha, S.,Fromme, P.,Kirian, R.A.,Martin-Garcia, J.M.,Ros, A.; Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme.; Lab Chip, 23:3016-3033, 2023; PubMed: 37294576; DOI: 10.1039/d3lc00176h

Experimental method

X-RAY DIFFRACTION (2.7 Å)