8C86

Crystal structure of human transthyretin in complex with 3-O-methyltolcapone analogue 2

8C86 の概要

• エントリーDOI: 10.2210/pdb8c86/pdb
• 関連するPDBエントリー: 6SUH
• 分子名称: Transthyretin, (2,4-dimethylphenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone (3 entities in total)
• 機能のキーワード: amyloidosis, tetramer, binding protein, transport protein, lipid binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28159.32

構造登録者

Poonsiri, T.,Benini, S.,Loconte, V.,Cianci, M. (登録日: 2023-01-18, 公開日: 2024-01-17, 最終更新日: 2024-01-24)

• 主引用文献: Poonsiri, T.,Dell'Accantera, D.,Loconte, V.,Casnati, A.,Cervoni, L.,Arcovito, A.,Benini, S.,Ferrari, A.,Cipolloni, M.,Cacioni, E.,De Franco, F.,Giacche, N.,Rinaldo, S.,Folli, C.,Sansone, F.,Berni, R.,Cianci, M.; 3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity.; Int J Mol Sci, 25:-, 2023; PubMed: 38203650; DOI: 10.3390/ijms25010479

実験手法

X-RAY DIFFRACTION (1.1 Å)