8C79
Crystal structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase complexed with NADPH
Summary for 8C79
Entry DOI | 10.2210/pdb8c79/pdb |
Descriptor | 6-phosphogluconate dehydrogenase, decarboxylating, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | leishmania donovani, trypanosoma, pentose phosphate pathway, 6-phosphogluconate dehydrogenase, oxidoreductase, antioxidant defense, drug target |
Biological source | Leishmania donovani |
Total number of polymer chains | 2 |
Total formula weight | 105416.71 |
Authors | Fritz-Wolf, K.,Berneburg, I.,Rahlfs, S.,Becker, K. (deposition date: 2023-01-13, release date: 2023-05-24, Last modification date: 2024-02-07) |
Primary citation | Berneburg, I.,Stumpf, M.,Velten, A.S.,Rahlfs, S.,Przyborski, J.,Becker, K.,Fritz-Wolf, K. Structure of Leishmania donovani 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment. Int J Mol Sci, 24:-, 2023 Cited by PubMed: 37239962DOI: 10.3390/ijms24108615 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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