8C64
Crystal structure of arsenoplatin-1/B-DNA adduct obtained upon 48 h of soaking
Summary for 8C64
Entry DOI | 10.2210/pdb8c64/pdb |
Related | 8C62 8C63 |
Descriptor | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), PLATINUM (II) ION, arsenoplatin-1, ... (4 entities in total) |
Functional Keywords | duplex, b-dna, arsenoplatin-1, anticancer agent, metallodrug, dna |
Biological source | synthetic construct |
Total number of polymer chains | 2 |
Total formula weight | 8135.06 |
Authors | Troisi, R.,Tito, G.,Ferraro, G.,Sica, F.,Merlino, A. (deposition date: 2023-01-11, release date: 2024-01-31, Last modification date: 2024-02-28) |
Primary citation | Troisi, R.,Tito, G.,Ferraro, G.,Sica, F.,Massai, L.,Geri, A.,Cirri, D.,Messori, L.,Merlino, A. On the mechanism of action of arsenoplatins: arsenoplatin-1 binding to a B-DNA dodecamer. Dalton Trans, 53:3476-3483, 2024 Cited by PubMed: 38270175DOI: 10.1039/d3dt04302a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
Download full validation report