8C49
Crystal structure of pyrrolysyl-tRNA synthetase from Methanomethylophilus alvus engineered for 3-Methyl-L-histidine, bound to AMPPNP
Summary for 8C49
| Entry DOI | 10.2210/pdb8c49/pdb |
| Descriptor | Pyrrolysyl-tRNA synthetase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
| Functional Keywords | pyrrolysyl-trna synthetase, genetic code expansion, engineered translation components, methanomethylophilus alvus, ligase |
| Biological source | Candidatus Methanomethylophilus alvus |
| Total number of polymer chains | 2 |
| Total formula weight | 66439.65 |
| Authors | Hardy, F.J.,Levy, C.W. (deposition date: 2023-01-03, release date: 2023-07-19, Last modification date: 2024-02-07) |
| Primary citation | Taylor, C.J.,Hardy, F.J.,Burke, A.J.,Bednar, R.M.,Mehl, R.A.,Green, A.P.,Lovelock, S.L. Engineering mutually orthogonal PylRS/tRNA pairs for dual encoding of functional histidine analogues. Protein Sci., 32:e4640-e4640, 2023 Cited by PubMed: 37051694DOI: 10.1002/pro.4640 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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