8C1Y

Small molecule stabilizer for 14-3-3/ChREBP (Cmd 30)

Summary for 8C1Y

• Entry DOI: 10.2210/pdb8c1y/pdb
• Descriptor: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, [2-[2-[[2,2-bis(fluoranyl)-2-phenyl-ethyl]amino]-2-oxidanylidene-ethoxy]phenyl]phosphonic acid, ... (4 entities in total)
• Functional Keywords: 14-3-3, chrebp, stabilization, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 29297.94

Authors

Pennings, M.A.M.,Visser, E.J.,Ottmann, C. (deposition date: 2022-12-21, release date: 2024-05-01)

• Primary citation: Katz, L.S.,Visser, E.J.,Plitzko, K.F.,Pennings, M.,Cossar, P.J.,Tse, I.L.,Kaiser, M.,Brunsveld, L.,Scott, D.K.,Ottmann, C.; Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.; Biorxiv, 2024; PubMed: 38405965; DOI: 10.1101/2024.02.16.580675

Experimental method

X-RAY DIFFRACTION (1.8 Å)