8C1G

Aurora A kinase in complex with TPX2-inhibitor 7

Summary for 8C1G

• Entry DOI: 10.2210/pdb8c1g/pdb
• Descriptor: Aurora kinase A, 4-(4-chlorophenyl)-~{N}-(dimethylsulfamoyl)-7-methyl-1~{H}-indole-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, ... (10 entities in total)
• Functional Keywords: protein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32770.03

Authors

Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2022-12-20, release date: 2024-01-10)

• Primary citation: Stockwell, S.,Scott, D.,Fischer, G.,Guarino Almeida, E.,Rooney, T.,Feng, J.,Moschetti, T.,Dagostin, C.,Alcaide-Lopez, A.,Rocaboy, M.,Srinivasan, R.,Asteian, A.,Alza, E.,Blaszczyk, B.,Wang, X.,Rossmann, M.,Perrior, T.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.,Hyvonen, M.; Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.96 Å)