8C1D
Aurora A kinase in complex with TPX2-inhibitor 9
Summary for 8C1D
Entry DOI | 10.2210/pdb8c1d/pdb |
Descriptor | Aurora kinase A, 4-(4-chlorophenyl)-7-methyl-1~{H}-indole-6-carboxylic acid, ADENOSINE-5'-DIPHOSPHATE, ... (9 entities in total) |
Functional Keywords | protein-ligand complex, kinase, protein-protein interaction inhibitor, cell cycle |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32475.73 |
Authors | Fischer, G.,Rocaboy, M.,Blaszczyk, B.,Moschetti, T.,Wang, X.,Scott, D.E.,Coyne, A.G.,Dagostin, C.,Rooney, T.,Bayly, A.,Feng, J.,Asteian, A.,Alcaide-Lopez, A.,Stockwell, S.,Skidmore, J.,Venkitaraman, A.R.,Abell, C.,Blundell, T.L.,Hyvonen, M. (deposition date: 2022-12-20, release date: 2024-01-10) |
Primary citation | Stockwell, S.,Scott, D.,Fischer, G.,Guarino Almeida, E.,Rooney, T.,Feng, J.,Moschetti, T.,Dagostin, C.,Alcaide-Lopez, A.,Rocaboy, M.,Srinivasan, R.,Asteian, A.,Alza, E.,Blaszczyk, B.,Wang, X.,Rossmann, M.,Perrior, T.,Blundell, T.L.,Spring, D.R.,McKenzie, G.,Abell, C.,Skidmore, J.,Venkitaraman, A.,Hyvonen, M. Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agent To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.115 Å) |
Structure validation
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