8C0P
Crystal structure of S. aureus BlaR1 sensor domain in complex with a boronate inhibitor
Summary for 8C0P
Entry DOI | 10.2210/pdb8c0p/pdb |
Descriptor | Regulatory protein BlaR1, [1-[[2,4-bis(trifluoromethyl)phenyl]methyl]benzimidazol-2-yl]sulfanylmethyl-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total) |
Functional Keywords | antibiotic resistance, beta-lactam sensor of staphylococcus aureus, mrsa, signaling protein |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 2 |
Total formula weight | 60443.21 |
Authors | Miguel-Ruano, V.,Jimenez-Faraco, E.,Hermoso, J.A. (deposition date: 2022-12-19, release date: 2024-07-10, Last modification date: 2024-09-04) |
Primary citation | Nguyen, V.T.,Birhanu, B.T.,Miguel-Ruano, V.,Kim, C.,Batuecas, M.,Yang, J.,El-Araby, A.M.,Jimenez-Faraco, E.,Schroeder, V.A.,Alba, A.,Rana, N.,Sader, S.,Thomas, C.A.,Feltzer, R.,Lee, M.,Fisher, J.F.,Hermoso, J.A.,Chang, M.,Mobashery, S. Restoring susceptibility to beta-lactam antibiotics in methicillin-resistant Staphylococcus aureus. Nat.Chem.Biol., 2024 Cited by PubMed: 39060390DOI: 10.1038/s41589-024-01688-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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