8BYU

Crystal Structure of HexaBody-CD38 Fab in complex with CD38

Summary for 8BYU

Entry DOI	10.2210/pdb8byu/pdb
Descriptor	Fab Heavy Chain, Fab Light Chain, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, ... (7 entities in total)
Functional Keywords	cd38, antibody, cdc, hexabody, anti-tumor, antitumor protein
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	79571.13
Authors	Freier, R.,Krapp, S.,Hibbert, R.G. (deposition date: 2022-12-14, release date: 2023-07-12, Last modification date: 2024-02-07)
Primary citation	Hiemstra, I.H.,Santegoets, K.C.M.,Janmaat, M.L.,De Goeij, B.E.C.G.,Ten Hagen, W.,van Dooremalen, S.,Boross, P.,van den Brakel, J.,Bosgra, S.,Andringa, G.,van Kessel-Welmers, B.,Verzijl, D.,Hibbert, R.G.,Frerichs, K.A.,Mutis, T.,van de Donk, N.W.C.J.,Ahmadi, T.,Satijn, D.,Sasser, A.K.,Breij, E.C.W. Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity. Ebiomedicine, 93:104663-104663, 2023 Cited by PubMed: 37379657 DOI: 10.1016/j.ebiom.2023.104663 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation