8BYO

fragment-linked stabilizer for ERa - 14-3-3 interaction (1074361)

Summary for 8BYO

• Entry DOI: 10.2210/pdb8byo/pdb
• Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: 14-3-3, era, fragment linking, stabilization, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 27661.34

Authors

Visser, E.J.,Vandenboorn, E.M.F.,Ottmann, C. (deposition date: 2023-01-18, release date: 2023-08-02, Last modification date: 2023-09-13)

• Primary citation: Visser, E.J.,Jaishankar, P.,Sijbesma, E.,Pennings, M.A.M.,Vandenboorn, E.M.F.,Guillory, X.,Neitz, R.J.,Morrow, J.,Dutta, S.,Renslo, A.R.,Brunsveld, L.,Arkin, M.R.,Ottmann, C.; From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.; Angew.Chem.Int.Ed.Engl., 62:e202308004-e202308004, 2023; PubMed: 37455289; DOI: 10.1002/anie.202308004

Experimental method

X-RAY DIFFRACTION (1.2 Å)