8BWP
Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with methotrexate)
Summary for 8BWP
| Entry DOI | 10.2210/pdb8bwp/pdb |
| Related | 8BJF 8BWO |
| EMDB information | 16088 16292 16293 |
| Descriptor | ATP-binding cassette sub-family C member 4, METHOTREXATE (2 entities in total) |
| Functional Keywords | abc transporter, abcc4, mrp4, translocase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 150148.36 |
| Authors | Raj, I.,Bloch, M.,Pape, T.H.,Taylor, N.M.I. (deposition date: 2022-12-07, release date: 2023-08-30, Last modification date: 2023-11-15) |
| Primary citation | Bloch, M.,Raj, I.,Pape, T.,Taylor, N.M.I. Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4. Structure, 31:1407-1418.e6, 2023 Cited by PubMed: 37683641DOI: 10.1016/j.str.2023.08.014 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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