8BWL
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium
Summary for 8BWL
Entry DOI | 10.2210/pdb8bwl/pdb |
Descriptor | Growth/differentiation factor 5, Twisted gastrulation protein homolog 1, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | twisted gastrulation protein homolog 1 (twsg1), growth differentiation factor 5 (gdf5), transforming growth factor beta (tgf-beta) signalling pathway, extracellular protein., signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 42619.46 |
Authors | Malinauskas, T.,Rudolf, A.F.,Moore, G.,Eggington, H.,Belnoue-Davis, H.,El Omari, K.,Woolley, R.E.,Griffiths, S.C.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.,Siebold, C. (deposition date: 2022-12-06, release date: 2024-06-19) |
Primary citation | Malinauskas, T.,Moore, G.,Rudolf, A.F.,Eggington, H.,Belnoue-Davis, H.L.,El Omari, K.,Griffiths, S.C.,Woolley, R.E.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.L.,Siebold, C. Molecular mechanism of BMP signal control by Twisted gastrulation. Nat Commun, 15:4976-4976, 2024 Cited by PubMed: 38862520DOI: 10.1038/s41467-024-49065-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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