8BWL

Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation factor 5 (GDF5) and calcium

8BWL の概要

• エントリーDOI: 10.2210/pdb8bwl/pdb
• 分子名称: Growth/differentiation factor 5, Twisted gastrulation protein homolog 1, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: twisted gastrulation protein homolog 1 (twsg1), growth differentiation factor 5 (gdf5), transforming growth factor beta (tgf-beta) signalling pathway, extracellular protein., signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 42619.46

構造登録者

Malinauskas, T.,Rudolf, A.F.,Moore, G.,Eggington, H.,Belnoue-Davis, H.,El Omari, K.,Woolley, R.E.,Griffiths, S.C.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.,Siebold, C. (登録日: 2022-12-06, 公開日: 2024-06-19)

• 主引用文献: Malinauskas, T.,Moore, G.,Rudolf, A.F.,Eggington, H.,Belnoue-Davis, H.L.,El Omari, K.,Griffiths, S.C.,Woolley, R.E.,Duman, R.,Wagner, A.,Leedham, S.J.,Baldock, C.,Ashe, H.L.,Siebold, C.; Molecular mechanism of BMP signal control by Twisted gastrulation.; Nat Commun, 15:4976-4976, 2024; PubMed: 38862520; DOI: 10.1038/s41467-024-49065-8

実験手法

X-RAY DIFFRACTION (1.96 Å)