8BV2

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

8BV2 の概要

• エントリーDOI: 10.2210/pdb8bv2/pdb
• 分子名称: Integrase, (2S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-chromen-6-yl)-6-methyl-phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: inhibitors, integrase, hiv-1, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20654.52

構造登録者

Ruff, M.,Benarous, R. (登録日: 2022-12-01, 公開日: 2023-06-07, 最終更新日: 2023-07-26)

• 主引用文献: Bonnard, D.,Le Rouzic, E.,Singer, M.R.,Yu, Z.,Le Strat, F.,Batisse, C.,Batisse, J.,Amadori, C.,Chasset, S.,Pye, V.E.,Emiliani, S.,Ledoussal, B.,Ruff, M.,Moreau, F.,Cherepanov, P.,Benarous, R.; Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.; Antimicrob.Agents Chemother., 67:e0046223-e0046223, 2023; PubMed: 37310224; DOI: 10.1128/aac.00462-23

実験手法

X-RAY DIFFRACTION (2 Å)