8BTB

Hexameric human IgG3 Fc complex

Summary for 8BTB

• Entry DOI: 10.2210/pdb8btb/pdb
• EMDB information: 16227
• Descriptor: FLJ00385 protein (Fragment) (2 entities in total)
• Functional Keywords: igg3, antibody, fc hexamer, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 12
• Total formula weight: 285311.40

Authors

Abendstein, L.,Sharp, T.H. (deposition date: 2022-11-28, release date: 2023-06-21, Last modification date: 2023-07-19)

• Primary citation: Abendstein, L.,Dijkstra, D.J.,Tjokrodirijo, R.T.N.,van Veelen, P.A.,Trouw, L.A.,Hensbergen, P.J.,Sharp, T.H.; Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains.; Nat Commun, 14:4027-4027, 2023; PubMed: 37419978; DOI: 10.1038/s41467-023-39788-5

Experimental method

ELECTRON MICROSCOPY (14 Å)