8BSQ

Notum Inhibitor ARUK3006561

Summary for 8BSQ

Entry DOI	10.2210/pdb8bsq/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, SULFATE ION, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	inhibitor notum, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	44662.09
Authors	Zhao, Y.,Jones, E.Y.,Fish, P. (deposition date: 2022-11-26, release date: 2022-12-14, Last modification date: 2023-06-28)
Primary citation	Atkinson, B.N.,Willis, N.J.,Zhao, Y.,Patel, C.,Frew, S.,Costelloe, K.,Magno, L.,Svensson, F.,Jones, E.Y.,Fish, P.V. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251:115132-115132, 2023 Cited by PubMed: 36934521 DOI: 10.1016/j.ejmech.2023.115132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation