8BQ7

Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH2829

8BQ7 の概要

• エントリーDOI: 10.2210/pdb8bq7/pdb
• 分子名称: N-glycosylase/DNA lyase, ~{N}4-cyclohexyl-2~{H}-pyrazolo[3,4-d]pyrimidine-4,6-diamine, NICKEL (II) ION, ... (5 entities in total)
• 機能のキーワード: ogg1, dna binding protein
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107833.03

構造登録者

Scaletti, E.,Stenmark, P. (登録日: 2022-11-19, 公開日: 2023-11-29, 最終更新日: 2026-03-04)

• 主引用文献: Hank, E.C.,D’Arcy-Evans, N.D.,Scaletti, E.R.,Benitez-Buelga, C.,Wallner, O.,Ortis, F.,Zhou, K.,Meng, L.,del Prado, A.,Calvo, P.,Almlof, I.,Wiita, E.,Nierlin, K.,Kosenina, S.,Kramer, A.,Eddershaw, A.,Kehler, M.,Long, M.,Jemth, A.S.,Dawson, H.,Stewart, J.,Dickey, A.,Astorga, M.E.,Varga, M.,Homan, E.J.,Scobie, M.,Knapp, S.,Sastre, L.,Stenmark, P.,de Vega, M.,Helleday, T.,Michel, M.; Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1; Rsc Chem Biol, 2025; DOI: 10.1039/D4CB00323C

実験手法

X-RAY DIFFRACTION (2.6 Å)