8BQ4
Crystal Structure of Phosphatidylinositol 5-Phosphate 4-Kinase (PI5P4K2C) bound to an inhibitor
Summary for 8BQ4
Entry DOI | 10.2210/pdb8bq4/pdb |
Descriptor | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma, 6-methyl-~{N}-(4-methylsulfonylphenyl)thieno[2,3-d]pyrimidin-4-amine (3 entities in total) |
Functional Keywords | lipid kinase, atp-competitive inhibitor, phosphatidylinositol 5-phosphate, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 84674.64 |
Authors | Ogg, D.J.,Howard, T.D. (deposition date: 2022-11-18, release date: 2022-12-28, Last modification date: 2024-02-07) |
Primary citation | Rooney, T.P.C.,Aldred, G.G.,Boffey, H.K.,Willems, H.M.G.,Edwards, S.,Chawner, S.J.,Scott, D.E.,Green, C.,Winpenny, D.,Skidmore, J.,Clarke, J.H.,Andrews, S.P. The Identification of Potent, Selective, and Brain Penetrant PI5P4K gamma Inhibitors as In Vivo-Ready Tool Molecules. J.Med.Chem., 66:804-821, 2023 Cited by PubMed: 36516442DOI: 10.1021/acs.jmedchem.2c01693 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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