8BPY

X-RAY STRUCTURE OF PDE9A IN COMPLEX WITH Inhibitor 13A

Summary for 8BPY

Entry DOI	10.2210/pdb8bpy/pdb
Descriptor	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	pde9a, inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	75025.89
Authors	Steuber, H. (deposition date: 2022-11-18, release date: 2022-12-28, Last modification date: 2023-01-11)
Primary citation	Meibom, D.,Micus, S.,Andreevski, A.L.,Anlauf, S.,Bogner, P.,von Buehler, C.J.,Dieskau, A.P.,Dreher, J.,Eitner, F.,Fliegner, D.,Follmann, M.,Gericke, K.M.,Maassen, S.,Meyer, J.,Schlemmer, K.H.,Steuber, H.,Tersteegen, A.,Wunder, F. BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor. J.Med.Chem., 65:16420-16431, 2022 Cited by PubMed: 36475653 DOI: 10.1021/acs.jmedchem.2c01267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation