8BLR

G13D mutant of KRAS4b (2-169) bound to GDP with the switch-I in fully open conformation

Summary for 8BLR

Entry DOI	10.2210/pdb8blr/pdb
Descriptor	GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE (3 entities in total)
Functional Keywords	kras, colorectal cancer, ras signalling, cancer stem cells, ras-driven metastasis, kras structure, kras mutations, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	19906.11
Authors	Moche, M.,Jungholm, O.,Strandback, E.,Ampah-Korsah, H.,Nyman, T.,Orwar, O. (deposition date: 2022-11-10, release date: 2024-05-22, Last modification date: 2024-09-11)
Primary citation	Jungholm, O.,Trkulja, C.,Moche, M.,Srinivasa, S.P.,Christakopoulou, M.N.,Davidson, M.,Reymer, A.,Jardemark, K.,Fogaca, R.L.,Ashok, A.,Jeffries, G.,Ampah-Korsah, H.,Strandback, E.,Andrell, J.,Nyman, T.,Nouairia, G.,Orwar, O. Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody. Sci Rep, 14:19656-19656, 2024 Cited by PubMed: 39179604 DOI: 10.1038/s41598-024-70217-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation