8BK3

Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with diepoxide ketone 1

Summary for 8BK3

Entry DOI	10.2210/pdb8bk3/pdb
Descriptor	L,D-transpeptidase 2, 1-[(2~{S},3~{R})-3-phenyloxiran-2-yl]ethanone, NITRATE ION, ... (7 entities in total)
Functional Keywords	l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	76738.92
Authors	de Munnik, M.,Schofield, C.J. (deposition date: 2022-11-08, release date: 2023-11-22)
Primary citation	de Munnik, M.,Lithgow, J.,Brewitz, L.,Christensen, K.E.,Bates, R.H.,Rodriguez-Miquel, B.,Schofield, C.J. alpha beta , alpha ' beta '-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes. Chem.Commun.(Camb.), 59:12859-12862, 2023 Cited by PubMed: 37815791 DOI: 10.1039/d3cc02932h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation